What is Retatrutide?
Retatrutide is a weight-loss peptide being studied for obesity and weight management. Unlike approaches that target one or two hormone pathways, retatrutide acts on three — GLP-1, GIP and glucagon — which are involved in appetite, metabolism and weight regulation.
Why Retatrutide?
Weight Loss
Clinical trials have shown substantial reductions in body weight, particularly at higher doses and over longer treatment periods.
Appetite Control
Acts on hormone pathways involved in hunger, fullness and food intake, helping reduce appetite and overall calorie consumption.
Triple-Action Approach
Targets GLP-1, GIP and glucagon receptors, giving retatrutide a broader mechanism of action than single or dual receptor approaches.
Who is Retatrutide Popular With?
Retatrutide is primarily of interest to people focused on significant weight loss, appetite control and long-term weight management. It has attracted particular attention because of the substantial weight reductions reported in clinical trials and its triple-action mechanism.
Research & Evidence
Retatrutide has been studied in clinical trials for obesity and weight management, with substantial reductions in body weight reported across Phase 2 and Phase 3 research.
Phase 2 — 24.2% Average Weight Loss
In a 48-week clinical trial involving 338 adults, participants receiving 12mg retatrutide lost an average of 24.2% of their starting body weight, compared with 2.1% with placebo. Weight loss had not yet plateaued at the end of the trial.
Phase 3 — 28.7% Average Weight Loss
In the TRIUMPH-4 Phase 3 trial, participants receiving 12mg retatrutide lost an average of 28.7% of their body weight over 68 weeks — approximately 32.3kg on average. The trial involved adults with obesity or overweight and knee osteoarthritis.
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Grant Mckenzie –
I started 1mg on Monday and I’m feeling great. Enough appetite that I can hit my high protein goals but 0 food noise!!!! My after dinner snacking was out of control for months before I started this and now I don’t even think about snacking. I’m planning on staying at 1mg for as long as it’s working, no plans to increase at all! But my mum who is overweight and diabetic started the same dose on Monday too and she said she’s still quite hungry. But I’m doing carnivore and she’s calorie counting at a deficit with balanced macros. Diet makes a huge difference.
Lindsy Colner –
I dropped 7 kilos in just 8 weeks. I didn’t really feel much appetite suppression, but I stuck to the protocol — eating healthy, prioritizing protein, and training 5 days a week. I never went above 2 mg per week. I’m planning a 12‑week run now. My goal was to go from 19% body fat to 12%, and I’m already at 13.5%. I’m really happy with the results.
Alex Ungerer –
After my trip in March, I decided to start Reta. I started at 0.5 mg for about three weeks and didn’t notice much. Once I increased to 1 mg, everything changed for me. One of the biggest differences wasn’t just my weight, it was how my relationship with food and alcohol changed. I lost the desire to drink, my appetite decreased a lot, and it became much easier to stick to healthier habits. I still worked out and golfed, but I finally felt like my choices were supporting my goals instead of working against them. Over the next five months, I lost a significant amount of weight and gained confidence. I feel comfortable wearing clothes I never would’ve worn before, going out with friends, and just enjoying life more.
Valarie Magruder –
Love Reta! I’ve been using it for 11 days and lost 4kgs. my body is changing fast but more importantly my body just feels better. Nighttime binging gone. Morning sugar weakness gone. Aches and stiffness gone. I will continue.