What is LGD-4033?
LGD-4033, also known as Ligandrol, is a selective androgen receptor modulator (SARM) developed to produce anabolic effects in tissues such as muscle. Its main appeal is lean mass: unlike a general stimulant or fat burner, LGD-4033 directly targets androgen signalling involved in building and maintaining muscle tissue.
Why LGD-4033?
Lean Muscle
Controlled human trials have demonstrated increases in lean body mass, giving LGD-4033 unusually direct human evidence for a SARM.
Body Composition
Its anabolic activity makes LGD-4033 particularly relevant when adding or preserving lean tissue is the main body-composition goal.
Human Evidence
Unlike many compounds popular in fitness circles, LGD-4033 has produced dose-dependent increases in lean mass in controlled human research.
Who is LGD-4033 Popular With?
LGD-4033 is particularly popular with gym-goers and bodybuilders focused on increasing lean mass and improving body composition. Its appeal comes from its anabolic activity in muscle combined with controlled human research demonstrating measurable increases in lean body mass, making it one of the better-studied SARMs for this particular outcome.
Research & Evidence
LGD-4033 has controlled human research showing increases in lean body mass. The evidence is stronger for gaining lean mass than for improving strength or athletic performance, so the research is best understood as evidence of an anabolic effect rather than proof of specific gym-performance outcomes.
Healthy Men — Lean Mass Increased in 21 Days
In a randomised, placebo-controlled study of 76 healthy men aged 21–50, LGD-4033 produced dose-dependent increases in lean body mass after only 21 days. The highest-dose group gained approximately 1.21kg of lean mass on average, while fat mass did not significantly change. The short study did not demonstrate a significant improvement in strength.
Phase 2 — Up to 3.1kg More Lean Mass
A 12-week Phase 2 trial studied LGD-4033, under the development name VK5211, in 108 older adults recovering from hip fracture. All three groups receiving VK5211 gained significantly more lean body mass than placebo, with placebo-adjusted gains ranging from approximately 1.6kg to 3.1kg. The study population was recovering older adults, so these results should not be assumed to predict the same gains in healthy gym-goers.
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Mike Miller –
I ran it once before as an advanced lifter and added 15kgs to my bench in 8 weeks so it works for sure strength wise. I see a lot of people say they went from 85-100 on their bench with it but you can do that with just a bulk and 5×5. It took mine from 175 to 190 with possibly more but I stopped as my back started to act up when I maxed out. It added muscle for sure of around 2kgs of eating at maintenance but that recovery time was huge as I could do a heavy deadlift day and feel ready to do another the day after.
J Black –
Been running the LGD at 10mgs Ed for a week, definitely feels legit. Good pumps and increased fullness, decent strength as well and improved sleep.
Kyle Platini –
Good Stuff